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Glial Fibrillary Acidic Protein/GFAP: Type III Intermediate Filament Protein

This Leukemia inhibitory factor (LIF) is a cytokine encoded by the LIF gene. LIF is an IL-6 class protein that inhibits cell differentiation, affecting cell growth. A decrease in LIF levels signals the cells to differentiate. In developing embryos, trophectoderm expresses LIF. LIF binds to LIF-receptor (LIFR), present throughout the embryonic inner cell mass. During the blastocyst stage, the inner cell mass produces embryonic stem cells, and if we remove these cells from the inner cell mass, the embryo loses its LIF source. Leukemia inhibitory factor (LIF) is a cytokine encoded by the LIF gene. LIF is an IL-6 class protein that inhibits cell differentiation, affecting cell growth. A decrease in LIF levels signals the cells to differentiate. In developing embryos, trophectoderm expresses LIF. LIF binds to LIF-receptor (LIFR), present throughout the embryonic inner cell mass. During the blastocyst stage, the inner cell mass produces embryonic stem cells, and if we remove these cells from the inner cell mass, the embryo loses its LIF source.

Lif Stem Cell is a cellular process that involves the full life cycle of the cell, from the growth to programmed cell death. It plays important role in replacement of old cells and to increase in numbers whenever required. It is said that for every cell that dies, a new one should get created ,but this does not apply for all cells as we know. Life stem cell is one among the few which are responsible for its own creation along with supplying oxygen to all other functioning parts.

Glial fibrillary acidic protein (GFAP) is a type III intermediate filament protein belonging to the intermediate filament protein family. The GFAP gene in humans encodes the GFAP protein. The gene is located on chromosome 17. Several CNS cell types that include ependymal cells and astrocytes express GFAP proteins during development. Other human cells, such as keratinocytes, Leydig cells, chondrocytes, and osteocytes, also express GFAP. GFAP, along with the other three non-epithelial cells belonging to the same protein family, regulates the functions and structure of the cytoskeleton. Although many studies use GFAP as a cell marker, we have still not completely understood its role in the body.

Glial fibrillary acidic protein (GFAP) is a member of the type III intermediate filament family that forms vimentin-like filaments in astrocytes and differentiates astrocytes from other CNS cells. GFAP mutations are linked to adrenoleukodystrophy, Alexander disease, and global amyloidosis with neurofibrillary tangles. Recently, oligomerized full-length human GFAP was identified as a novel cross-beta amyloid conformer in the brains of patients with neurodegenerative diseases such as Alzheimer’s disease, Creutzfeldt–Jakob disease, and Alexander disease. The present study aimed to better understand the mechanism underlying neurodegeneration associated with GFAP amyloid formation.

Glial fibrillary acidic protein (GFAP) is a type III intermediate filament protein belonging to the intermediate filament protein family. The GFAP gene in humans encodes the GFAP protein. The gene is located on chromosome 17. Several CNS cell types that include ependymal cells and astrocytes express GFAP proteins during development. Other human cells, such as keratinocytes, Leydig cells, chondrocytes, and osteocytes, also express GFAP.

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